Simple and Efficient Spherical Crystallization of Clopidogrel Bisulfate Form-I via Anti-Solvent Crystallization Method

Spherical crystallization of drugs.

Spherical crystallization of drugs is the process of obtaining larger particles by agglomeration during crystallization. The most common techniques used to obtain such particles are spherical agglomeration and quasi-emulsion solvent diffusion. Ammonia diffusion systems and crystallo-co-agglomeration are extensions of these techniques. By controlling process parameters during crystallization, su...

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Spherical Crystallization of Mefenamic Acid

*To whom all correspondence should be addressed. he quality of a solid pharmaceutical preparation is influenced by primary micromeritic characteristics such as the shape and size of drug crystals, especially when large amounts of poorly soluble drugs are formulated. To improve the dissolution rate of poorly soluble drugs, fine crystals are preferred over large crystals because they provide a gr...

Spherical crystallization: A method for improving powder and tablet characteristics

Direct tabletting technique is the modern and the most efficient process used in tablet manufacturing which has been successfully used for various drugs. But the process strongly depends upon the quality of the crystals used. For improvement of direct compression properties of different poorly soluble drugs Kawashima and their coworkers developed the spherical crystallization technique in 1986,...

Extraction and purification of crocin from saffron stigmas employing a simple and efficient crystallization method.

In this study, total crocin was extracted from saffron stigmas using crystallization method. Ethanol 80% was selected as the best extraction solvent. Crystallization process was carried out in one and two steps at different temperatures. Ethanol 80% was used as crystallization medium. Crocin crystals obtained from the first crystallization had low purity and thus were subjected to the second cr...